论文部分内容阅读
目的观察新诊断糖尿病成年男性患者性激素结合球蛋白(SHBG)的变化,探讨其与IR及胰岛早相分泌功能的关系。方法纳入新诊断糖尿病男性患者56例为糖尿病组,另选健康成年男性38名为正常对照组,测定SHBG,进行精氨酸刺激试验。结果两组SHBG、胰岛素抵抗指数(HOMAIR)差异有统计学意义(P<0.01)。相关分析显示,SHBG与HOMA-IR呈负相关(r=-0.219,P<0.05)。Logistic回归分析显示,SHBG是IR的唯一有效自变量(β=-0.75,P<0.05,OR=0.47)。二元Logistic回归分析得出HOMA-IR是糖尿病的危险因素,SHBG是糖尿病的保护因素。胰岛2min分泌高峰值与HOMA-IR呈正相关(β=0.567,P<0.05)。结论新诊断糖尿病成年男性患者存在血清SHBG降低,SHBG与HOMA-IR呈负相关。SHBG是新诊断糖尿病成年男性患者的独立保护因素。胰岛β细胞第一时相分泌功能减退与IR相关,与SHBG无相关性。
Objective To observe the changes of sex hormone binding globulin (SHBG) in adult male patients with newly diagnosed diabetes mellitus (DM) and to explore its relationship with IR and pancreatic islet secretory function. Methods Fifty-six male patients with newly diagnosed diabetes were selected as diabetic group and 38 healthy adult male as control group. SHBG was measured and arginine stimulation test was performed. Results There was significant difference in SHBG and HOMAIR between the two groups (P <0.01). Correlation analysis showed that SHBG was negatively correlated with HOMA-IR (r = -0.219, P <0.05). Logistic regression analysis showed that SHBG was the only valid independent variable of IR (β = -0.75, P <0.05, OR = 0.47). Binary Logistic regression analysis concluded that HOMA-IR is a risk factor for diabetes and SHBG is a protective factor for diabetes. The peak value of 2-minute insulin secretion was positively correlated with HOMA-IR (β = 0.567, P <0.05). Conclusion Serum SHBG is decreased in adult male patients with newly diagnosed diabetes, and SHBG is negatively correlated with HOMA-IR. SHBG is an independent protective factor in newly diagnosed adult male patients with diabetes. The first phase of pancreatic β-cell hypocellular dysfunction associated with IR, and no correlation with SHBG.