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目的:寻找一种与抗癌药物合并使用的增效药物。方法:用5%DMBA涂擦金黄地鼠颊囊诱发颊癌后,用平阳霉素局部注射和肌注治疗实验性癌的同时,用复方芪蓝合剂灌胃,观察其减轻抗癌药物毒副作用以及抗癌的增效作用。结果:实验组动物的毒副反应明显低于对照组,而且治愈率高于对照组(p<0.05)。结论:复方芪蓝中药制剂与抗癌药物合用对抗癌药物有增效作用,而且可以减轻抗癌药物的毒副作用。
Purpose: To find a synergistic drug that can be used in combination with anti-cancer drugs. Methods: After treated with 5% DMBA, the cheek pouch of golden hamster was treated with bupamycin for local injection and intramuscular injection of experimental cancer. The rats were treated with Compound Qilan Mixture by intragastric administration to observe the side effects of anticancer drugs As well as anti-cancer synergy. Results: The toxicity of the experimental group was significantly lower than that of the control group, and the cure rate was higher than that of the control group (p <0.05). Conclusion: Compound Qilan Chinese medicine and anticancer drugs combined with anti-cancer drugs have synergies, but also can reduce the side effects of anti-cancer drugs.