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目的 观察巴曲酶对寒潮促发的易卒中型肾血管性高血压大鼠(RHRSP)的卒中是否有预防作用。方法 用持续高血压1 0周、1 2周、1 4周、1 6周的RHRSP分巴曲酶预处理组和生理盐水对照组,于寒潮来临前1天经股静脉注射巴曲酶( 2BU/kg) ,1天后处死,TTC染色,HE染色。结果 脑卒中发生率在巴曲酶组较对照组显著降低(P <0 . 0 5) ,其中以出血性脑卒中为著。结论 巴曲酶可预防寒潮促发的高血压性脑卒中的发生,对出血性卒中的作用尤其显著。
Objective To observe whether Batroxobin can prevent the stroke caused by cold surge in stroke-prone renovascular hypertensive rats (RHRSP). Methods Pretreated with Rhubarb Curcumae RHRSP and saline control groups with continuous hypertension for 10 weeks, 12 weeks, 14 weeks, and 16 weeks respectively, Batroxobin (2BU / kg), sacrificed after 1 day, TTC stained, HE stained. Results The incidence of stroke was significantly lower in the Batroxobin group than in the control group (P <0.05), with hemorrhagic stroke being the most common cause. Conclusion Batroxobin can prevent the occurrence of cold stroke-induced hypertension stroke, especially for hemorrhagic stroke.