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本文研究了自广地龙中提出来的一种引湿性、淡黄色針状結晶(含量約0.2％)对平滑肌器官(特别是对子宮)的作用。介紹了該結晶的提取方法。該結晶0.1毫克加入25毫升Locke液中,能使已孕和未孕大鼠或豚鼠离体子宮角紧张度明显升高,0.3毫克可使之呈痙攣收縮状态。按1毫克/公斤給已孕和未孕麻醉家兔靜脉注射后15—30分钟,在位子宮紧张度升高,作用維持1.5—3小时。按8—10毫克/公斤注射,子宮紧张度立卽升高和血压急剧下降到零而死亡。9只慢性子宫瘻家兔靜脉注射(3—6毫克/公斤)或灌胃給药(10—20毫克/公斤)后15—45分钟,子宮收縮明显增强,作用維持1.5—3小时(注射給药)和7小时以上(灌胃給药)。多数实驗家兔在子宮兴奋同时有排便現象。該結晶对家兔在位腸管和大鼠后肢血管均有强烈兴奋作用,但对豚鼠支气管肌作用极弱。当給小鼠靜脉注射时,LD_(50)为38.7毫克/公斤。
This article investigates the effect of a hygroscopic, light yellow needle-like crystal (0.2% content) on smooth muscle organs (especially on the uterus) that has been proposed from the genus Cicerone. The extraction method of this crystal is introduced. The crystal 0.1mg added 25mL Locke solution, can make pregnant and non-pregnant rats or guinea pigs in vitro significantly increased uterine horn tension, 0.3mg can make it spastic contraction. Press 1 mg / kg to pregnant and non-pregnant anesthetized rabbits 15-30 minutes after intravenous injection in the uterus elevated tension, the role of maintaining 1.5-3 hours. By 8-10 mg / kg injection, uterine tension increased and blood pressure dropped sharply to zero and died. Nine chronic uterine fistula rabbits were intravenously injected (3-6 mg / kg) or 15-45 minutes after gavage (10-20 mg / kg) and the uterine contractions were significantly increased for 1.5-3 hours (injection Medicine) and more than 7 hours (gavage). Most experimental rabbits in the womb excited with defecation. The crystallization of rabbit intestinal and rat hind limb blood vessels have a strong excitement, but the role of guinea pig bronchial muscle very weak. When mice were injected intravenously, LD 50 was 38.7 mg / kg.