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目的探讨硫糖铝和黄连素联合应用治疗慢性顽固性胃炎的临床疗效。方法选取2012年1月至2014年1月于商丘市第三人民医院进行治疗的慢性顽固性胃炎患者200例,分为治疗组和对照组,每组100例,治疗组采用硫糖铝联合黄连素治疗,对照组单用黄连素治疗,治疗结束后比较两组患者的临床疗效及复发率。结果对试验结果进行统计分析,治疗组的临床总有效率为96%,而对照组临床总有效率为75%,治疗组显著高于对照组,差异有统计学意义(P<0.05);治疗组复发5例,对照组复发25例,治疗组显著少于对照组,差异有统计学意义(P<0.05),治疗期间均没有发生明显的不良反应。结论硫糖铝联合黄连素治疗慢性顽固性胃炎,临床效果显著,可有效降低复发率,安全可靠,值得在临床上进行推广应用。
Objective To investigate the clinical efficacy of sucralfate and berberine in the treatment of chronic intractable gastritis. Methods From January 2012 to January 2014 in Shangqiu Third People’s Hospital for treatment of chronic refractory gastritis patients 200 cases, divided into treatment group and control group, 100 cases in each group, the treatment group with sucralfate combined with Coptis The treatment group, the control group with berberine alone, after treatment, the clinical efficacy and recurrence rate of two groups were compared. Results The statistical analysis of the test results showed that the total clinical effective rate was 96% in the treatment group and 75% in the control group, which was significantly higher in the treatment group than in the control group (P <0.05) 5 cases relapsed, 25 cases relapsed in the control group, the treatment group was significantly less than the control group, the difference was statistically significant (P <0.05), no significant adverse reactions during the treatment. Conclusion Sucralfate combined with berberine in the treatment of chronic intractable gastritis has significant clinical effect, which can effectively reduce the recurrence rate and is safe and reliable. It is worth to be popularized and applied clinically.