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细胞需要面对包含活性氧族和亲电子剂等多种微环境损害,它们通过多种机制应对有毒或致癌物质的损伤。其中最重要的细胞防御机制是通过转录因子Nrf2(nuclear factor-erythroid 2 p45-related factor 2)调节的。大量的研究均证实,Nrf2能够抵御广谱的毒性物质和致病原对细胞的损伤。Nrf2介导的细胞保护反应无细胞特异性和器官特异性,Nrf2可保护肺脏、肝脏、消化道、神经系统和心血管系统等多种器官或组织。因此,Nrf2在多器官保护中具有巨大的治疗潜力。
Cells need to face a variety of microenvironmental damage, including reactive oxygen species and electrophiles, through a variety of mechanisms to deal with toxic or carcinogenic damage. One of the most important cellular defense mechanisms is regulated by the transcription factor Nrf2 (nuclear factor-erythroid 2 p45-related factor 2). Numerous studies have confirmed that Nrf2 can resist a wide range of toxic substances and pathogenic damage to cells. Nrf2-mediated cytoprotective responses are cell-and organ-specific, and Nrf2 protects many organs and tissues such as the lungs, liver, digestive tract, nervous system and cardiovascular system. Therefore, Nrf2 has tremendous therapeutic potential in multiple organ protection.