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目的:探讨复合乳酸菌胶囊联合乳果糖口服液治疗功能性便秘的疗效及预防复发作用。方法:功能性便秘患者86例随机分为观察组43例和对照组43例。对照组组患者予乳果糖口服液15 ml,po,tid,连用8周。观察组患者在此基础上加用复合乳酸菌胶囊0.66 g,po(餐后30 min温水服用),tid,连用8周。观察并比较两组患者的疗效及药物不良反应,比较治疗后随访6个月和1年内的复发率。结果:治疗8周后,观察组患者临床总有效率为95.35%,明显高于对照组的79.07%(P<0.05)。两组治疗期间药品不良反应发生率比较,差异无统计学意义(P>0.05)。治疗后随访观察6个月和1年,观察组患者的复发率(19.51%和31.71%)均明显低于对照组(41.18%和58.82%)(P<0.05)。结论:复合乳酸菌胶囊在乳果糖口服液治疗功能性便秘的过程中具有良好的协同和增效作用,安全性较佳,并能降低其复发率,具有预防复发的作用。
Objective: To investigate the efficacy and prevention of compound lactic acid bacteria capsule combined with lactulose oral liquid in the treatment of functional constipation. Methods: 86 patients with functional constipation were randomly divided into observation group 43 cases and control group 43 cases. Control group patients to lactulose oral solution 15 ml, po, tid, once every 8 weeks. On the basis of this observation group patients with compound lactic acid bacteria capsule 0.66 g, po (warm water after meal 30 min), tid, once every 8 weeks. The curative effect and adverse drug reactions of the two groups were observed and compared. The recurrence rates were compared between 6 months and 1 year after treatment. Results: After 8 weeks of treatment, the total effective rate in the observation group was 95.35%, significantly higher than that in the control group (79.07%, P <0.05). There was no significant difference in incidence of adverse drug reactions between the two groups during treatment (P> 0.05). Follow up for 6 months and 1 year after treatment, the recurrence rate (19.51% and 31.71%) in the observation group was significantly lower than that in the control group (41.18% and 58.82%, P <0.05). Conclusion: The compound lactic acid bacteria capsule has a good synergistic and synergistic effect in the treatment of functional constipation with lactulose oral liquid, which is safe and can reduce the recurrence rate and has the effect of preventing relapse.