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为了探讨慢性髓性白血病(CML)易感性与HLA-DRB1等位基因多态性之间的关联性,试图找出慢性髓性白血病的易感基因。采用序列特异性引物聚合酶链反应(PCR-SSP)DNA分型技术对48例CML患者和105例健康人对照组进行了HLA-DRB1基因分型。结果显示,CML与HLA-DR4基因关联,基因频率为22.9％,RR=5.076,x~2=17.88,P<0.01;其它等位基困频率在CML组与对照组间差异无显著性。提示在河南汉族人群中,HLA-DR4与CML有关联。
To investigate the association between susceptibility to chronic myelogenous leukemia (CML) and HLA-DRB1 allelic polymorphisms, attempts were made to identify susceptibility genes for chronic myelogenous leukemia. The HLA-DRB1 genotype was performed on 48 CML patients and 105 healthy controls using sequence-specific primer polymerase chain reaction (PCR-SSP) DNA typing technique. The results showed that CML was associated with HLA-DR4 gene, the gene frequency was 22.9%, RR=5.076, x~2=17.88, P<0.01; the other allelic trapping frequency had no significant difference between the CML group and the control group. It is suggested that HLA-DR4 is associated with CML in Henan Han population.