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环孢素A(cycloeporinA,CsA)为11个氨基酸组成的环形多肽,是从土壤霉菌中分离出来的一种强效、选择性高的免疫抑制剂。CsA广泛用于器官移植及免疫性疾病的治疗,近年来已被广泛用于治疗难治性肾病综合征和其他肾脏疾病。与其他免疫抑制剂相比,CsA的突出优点在于选择性地作用于T淋巴细胞,并不影响骨髓中的粒系和红系细胞。对部分传统免疫抑制治疗抵抗、依赖、甚至无效的肾病综合征患者,CsA仍然有效。
Cyclooxygenin (cycloeporin A, CsA) is a 11 amino acid cyclic peptide, which is a potent and selective immunosuppressant isolated from soil mold. CsA is widely used in the treatment of organ transplant and immune diseases and has been widely used in recent years to treat refractory nephrotic syndrome and other kidney diseases. The salient advantage of CsA over other immunosuppressive agents is that it selectively acts on T lymphocytes and does not affect myeloid and erythroid cells in the bone marrow. CsA is still effective for patients with nephrotic syndrome that are resistant, dependent, or even ineffective to some traditional immunosuppressive therapy.