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盆底功能障碍疾病是由于支持盆底的肌肉、筋膜、神经纤维等组织发生病变,导致盆底支持结构薄弱所致。随着健康意识的提高,对其关注也越来越多。盆底功能障碍疾病的发生与分娩损伤、子宫支持组织的疏松薄弱及长期腹压增加有关,但其发病机制迄今尚未完全明确。动物实验研究表明,类赖氨酰氧化酶1(LOXL-1)是弹性纤维发育成熟和保持内环境稳定的关键酶,Fibulin-5与LOXL-1协同以原纤维的形式分布于富含弹性蛋白的组织,能直接与原弹性蛋白结合,并将原弹性蛋白以特定的序列锚定于细胞表面,对弹性纤维的合成有促进作用。
Pelvic floor dysfunction disease is due to supporting the pelvic floor muscles, fascia, nerve fibers and other tissue lesions, resulting in pelvic floor support structure caused by weakness. With the improvement of health awareness, more and more attention is paid to it. The incidence of pelvic floor dysfunction and childbirth injury, uterine support loose loose tissue and long-term increase in abdominal pressure, but its pathogenesis has not yet fully clear. Animal experiments show that LOXL-1 is the key enzyme for the development of elastic fibers and the stability of the internal environment. Fibulin-5 cooperates with LOXL-1 in the form of fibrils in the form of fibrils rich in elastin Of the tissue that binds directly to the tropoelastin and anchors the tropoelastin to the cell surface in a specific sequence that promotes the synthesis of the elastic fibers.