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为了解无症状性心或脑缺血的非胰岛素依赖型糖尿病（ＮＩＤＤＭ）患者的血中肿瘤坏死因子－α（ＴＮＦ－α）及纤溶活性的变化，我们观察了２０例正常人、２５例ＮＩＤＤＭ伴无症状性心或脑缺血患者、１８例ＮＴＤＤＭ不伴无症状性心或脑缺血患者血中ＴＮＦ－α水平，组织型纤溶酶原激活剂（ｔ－ＰＡ）活性和ＰＡ抑制物（ＰＡＩ）活性的改变。结果显示：ＴＮＦ－α、ＰＡＩ在ＮＩＤＤＭ伴无症状缺血患者最高，而ｔ－ＰＡ最低。表明ＴＮＦ－α水平升高及纤溶活性降低参与了ＮＩＤＤＭ无症状性心或脑缺血的发生。
To investigate the changes of tumor necrosis factor-α (TNF-α) and fibrinolytic activity in blood of non-insulin-dependent diabetes mellitus (NIDDM) patients with asymptomatic cardiac or cerebral ischemia, we observed 20 normal subjects and 25 Tumor necrosis factor-α (TNF-α), tissue-type plasminogen activator (t-PA) activity and PA inhibition in 18 patients with NTDDM without asymptomatic cardiac or cerebral ischemia were significantly higher in NIDDM patients with asymptomatic heart or cerebral ischemia (PAI) activity changes. The results showed that: TNF-α, PAI in NIDDM patients with asymptomatic ischemia highest, and t-PA lowest. This indicates that elevated TNF-α levels and decreased fibrinolytic activity are involved in asymptomatic cardiac or cerebral ischemia in NIDDM.