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9只狗在五烷巴比妥静脉麻醉下分别静脉滴注汉肌松(HCS)或ATP降压;血流动力变化用Swan-Ganz漂浮导管和Gould IM1000电脑心脏监护仪测定,呼吸动力变化用多功能呼吸监护仪测定。HCS低压期间HR,SVR,LVSWI,和MVO_2呈显著降低,CI,SI,CVP,PAP,PCWP,PVR和RVSWI无显著变化。ATP降压期间SI显著增高,PVR,RVSWI显著降低。HCS或ATP降压期均无肺顺应性、气道阻力及气道峰值压力变化。HCS降压期吸气平台压显著降低,而ATP降压期无此变化。结果表明用HCS持续降压的优点是降压起效快、停药后复压快,可维持恒定的低压水平、左心负荷减轻、心肌氧耗量减少,无快速耐药性及复压期反跳性高血压和心动过速。二者的主要区别,HCS兼有弱的肌肉松弛作用,ATP使心脏每搏量增高和使右心负荷显著增高。HCS和ATP相似,可用于临床降压。
Nine dogs underwent pentobarbital intravenous anesthesia, respectively, by intravenous infusion of hamstringis (HCS) or ATP depressurization; changes in hemodynamic variables with Swan-Ganz floating catheter and Gould IM1000 computer monitor, measured changes in respiratory motility Multi-function respiratory monitor measurement. HR, SVR, LVSWI, and MVO_2 were significantly decreased during HCS low pressure, but no significant changes were observed in CI, SI, CVP, PAP, PCWP, PVR and RVSWI. SI was significantly increased during ATP deprivation, while PVR and RVSWI were significantly decreased. There was no lung compliance, airway resistance and peak airway pressure change during HCS or ATP depressurization. HCS depressurization inspiratory platform pressure decreased significantly, but no such changes during ATP depressurization. The results showed that the advantage of continuous blood pressure reduction with HCS is the rapid onset of antihypertensive effect, fasting pressure after withdrawal, to maintain a constant low pressure level, reduce left ventricular load, myocardial oxygen consumption decreased, no rapid resistance and repression period Rebound Hypertension and Tachycardia. The main difference between the two, HCS both weak muscle relaxation, ATP to increase the volume of cardiac stroke and right heart load was significantly higher. HCS and ATP are similar, can be used for clinical blood pressure.