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目的探讨肺结核并肺部真菌感染的临床、药敏及预后。方法应用回顾性调查方法对86例肺结核并肺部真菌感染的临床资料和相关因素进行分析。结果肺结核并肺部真菌感染率为20.9%(86/412),肺部真菌感染以白色念珠菌为主,占55.81%感染菌种对7种常用抗真菌药物的敏感性为:两性霉素B97.6%,氟康唑88.4%,益康唑、酮康唑、伊曲康唑、咪康唑有不同程度的耐药,而对制霉菌素有明显的耐药,达76%。应用广谱抗菌素、长期应用激素、侵入性操作、白细胞减少是肺结核并肺部真菌感染相关因素。结论肺结核并肺部真菌感染率高,预后差,病死率高。预防真菌感染是提高肺结核患者生存率的重要因素。
Objective To investigate the clinical, drug sensitivity and prognosis of pulmonary tuberculosis and pulmonary fungal infection. Methods The clinical data and related factors of 86 pulmonary tuberculosis and pulmonary fungal infections were analyzed retrospectively. Results Pulmonary tuberculosis and pulmonary fungal infection rate was 20.9% (86/412). Candida albicans was the main cause of pulmonary fungal infection, accounting for 55.81%. The sensitivity of the infected strains to 7 commonly used antifungal agents was amphotericin B97 .6%, fluconazole 88.4%, econazole, ketoconazole, itraconazole, miconazole have different degrees of resistance, and nystatin significant resistance, up to 76%. Application of broad-spectrum antibiotics, long-term use of hormones, invasive procedures, leukopenia is a pulmonary tuberculosis and pulmonary fungal infection-related factors. Conclusion Pulmonary tuberculosis and pulmonary fungal infection rate is high, the prognosis is poor, high mortality. Prevention of fungal infection is an important factor to improve the survival rate of patients with pulmonary tuberculosis.