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目的 研究细胞周期素D1(cyclinD1)在卵巢上皮性肿瘤中的表达及意义。方法 1997～ 2 0 0 0年采用免疫组织化学SP法 ,检测恶性卵巢上皮性肿瘤、交界性肿瘤、良性肿瘤、正常卵巢组织cyclinD1的表达。结果 在恶性卵巢上皮性肿瘤 ,良性肿瘤 ,正常卵巢组织之间cyclinD1的表达差异有显著性 (P <0 0 1)。cyclinD1的表达率与组织分化程度和临床分期有显著相关性 (P <0 0 5 ) ,cyclinD1的过度表达见于组织分化差 ,肿瘤发病的晚期。结论 cyclinD1在卵巢癌组织中广泛存在 ,并与组织分化 ,临床分期有一定相关性 ,提示该基因在卵巢癌的发生、发展中起一定作用
Objective To study the expression and significance of cyclin D1 in epithelial ovarian tumors. Methods Immunohistochemical SP method was used to detect the expression of cyclinD1 in malignant ovarian epithelial tumor, borderline tumor, benign tumor and normal ovary tissue from 1997 to 2000. Results The expression of cyclinD1 in malignant ovarian epithelial tumor, benign tumor and normal ovarian tissue was significantly different (P <0.01). The expression of cyclinD1 was significantly correlated with the degree of differentiation and clinical stage (P <0.05). Overexpression of cyclinD1 was found in poorly differentiated tissues and advanced stage of tumor. Conclusion CyclinD1 is widely expressed in ovarian cancer tissues and has some correlation with tissue differentiation and clinical stage, suggesting that cyclinD1 plays a role in the development and progression of ovarian cancer