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目的分析Ⅱ型糖尿病肾病与血流变、血脂和胰岛素抵抗的相关性。方法比较Ⅱ型糖尿病肾病组(DN)和无肾病的Ⅱ型糖尿病(DM)组的临床指标,并分析糖尿病肾病的相关危险因素。结果两组的收缩压(SBP)、舒张压(DBP)、脂蛋白a[Lp(a)]、低密度脂蛋白胆固醇(LDL-C)、全血粘度低切(BVL)、血浆粘度(ηp)、红细胞聚集指数(EAI)、血清胰岛素(FINS)有明显差异;Ⅱ型糖尿病肾病发生与SBP、Lp(a)、LDL-C、BVL、ηp、FINS呈正相关。多元逐步回归分析显示,影响糖尿病肾病的独立相关因素为SBP、Lp(a)、ηp、BVL和FINS。结论 SBP、Lp(a)、BVL、ηp和FINS是糖尿病肾病的主要危险因素。
Objective To analyze the relationship between type 2 diabetic nephropathy and blood rheology, blood lipids and insulin resistance. Methods The clinical data of patients with type Ⅱ diabetic nephropathy (DN) and without nephropathy (type 2 diabetes mellitus) were compared and the related risk factors of diabetic nephropathy were analyzed. Results SBP, DBP, Lp (a), LDL-C, BVL, plasma viscosity (ηp ), Erythrocyte aggregation index (EAI) and serum insulin (FINS). There was a positive correlation between type II diabetic nephropathy and SBP, Lp (a), LDL-C, BVL, Multivariate stepwise regression analysis showed that SBP, Lp (a), ηp, BVL and FINS were the independent factors affecting diabetic nephropathy. Conclusion SBP, Lp (a), BVL, ηp and FINS are the main risk factors of diabetic nephropathy.