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癌发生的主要因素发挥作用,细胞则癌变。在癌变细胞开始增殖的癌发生初期,癌细胞仍受免疫系统抑制。在极早期癌所见的不伴血管新生的组织象与局限于发癌部组织内的微小癌,也可以说受到局部维护机制控制。在这种微小癌脱离机体维护机制而浸润的过程中,如果有对肿瘤的免疫应答,也直接表现在增殖局部。事实上,大部分肿瘤增殖部位与固有间质中都有各种各样的细胞反应。一般认为,癌组织中细胞浸润程度强的宿主预后较好。
The main factors of carcinogenesis play a role, and the cells are cancerous. In the early stages of the onset of cancer in which the cancerous cells begin to proliferate, the cancer cells are still inhibited by the immune system. Tissues that do not have angiogenesis seen in very early stages of cancer can be said to be controlled by local maintenance mechanisms as well as microscopic cancers that are confined to the cancerous tissue. In the course of infiltration of such microcancers out of the body’s maintenance mechanism, if there is an immune response to the tumor, it is also directly manifested in the proliferation. In fact, there are a variety of cellular responses in most areas of tumor proliferation and intrinsic stroma. It is generally believed that a host with a high degree of cell infiltration in a cancer tissue has a better prognosis.