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Objectives To study the relationship between plasma BNP and cardiac structural,functional changes after AMI, and to evaluate the application of plasma BNP determination in predicting the early phase of ventricle remodeling after AMI.Methods AMI group included 37 patients,all patient underwent strict medical treatment;32 healthy individuals were enrolled as controls.Plasma BNP was determinated by immunofluorescence.Echocardiogram examination was used to determinate LVEF,V_E,V_A,V_E/ V_A,LVEDd,LVEDV;All patients underwent the examinations at 72 h,30 days and 90 days after AMI occurred,respectively,and were compared with healthy controls.Results In comparing to controls,Plasma BNP in AMI 72 h,30 days and 90 days elevated significantly.LVEDd and LVEDV were increased significantly in all 3 phases of AMI,and EF,V_E/V_A were significantly lower than in controls.Correlation analysis revealed that plasma BNP level in 72 h after AMI was positively correlated to LVEDd,LVEDV,and was positively correlated to EF,V_E/ V_A in 30 days and 90 days after AMI.Conclusions Plasma BNP level in 72 h after AMI is a powerful index to predict left ventricle remodeling and ventricle function as plasm BNP level is positively correlated to ventricle remodeling;lowering the plasm BNP level might be used as an end point for treatment of heart failure.
Objectives To study the relationship between plasma BNP and cardiac structural, functional changes after AMI, and to evaluate the application of plasma BNP determination in predicting the early phase of ventricular remodeling after AMI. Methods AMI group included 37 patients, all patient underwent strict medical treatment ; 32 healthy individuals were enrolled as controls. Plasma BNP was determinated by immunofluorescence. Echocardiogram examination was used to determinate LVEF, V_E, V_A, V_E / V_A, LVEDd, LVEDV; All patients underwent the examinations at 72 h, 30 days and 90 days After AMI occurred, respectively, and were compared with healthy controls. Results In Comparison to Controls, Plasma BNP in AMI 72 h, 30 days and 90 days significantly elevated. LVEDd and LVEDV were significantly increased in all 3 phases of AMI, and EF, V_E / V_A were significantly lower than in controls. Correlation analysis revealed that plasma BNP level in 72 h after AMI was positively correlated to LVEDd, LVEDV, and was positively cor related to EF, V_E / V_A in 30 days and 90 days after AMI. Conclusions Plasma BNP level in 72 h after AMI is a powerful index to predict left ventricle remodeling and ventricle function as plasm; BNP level is positively correlated to ventricle remodeling; lowering the plasm BNP level might be used as an end point for treatment of heart failure.