论文部分内容阅读
目的:探讨原发性鼻腔透明细胞癌的临床表现及病理特点,总结其诊断及治疗方法。方法:分析1例原发性鼻腔透明细胞癌患者的临床资料,复习1992年以来11例相关文献,做出总结报道。结果:12例原发性鼻腔-鼻窦透明细胞癌中8例(66.7%)主要表现为鼻出血,4例(33.3%)出现骨质破坏;CT显示鼻腔、鼻窦内条片状类似软组织密度影,行单纯手术切除治疗3例(25.0%),手术切除联合放、化疗7例(58.3%),单纯放化疗2例(16.7%)。治疗后随访6个月～10年,仅1例患者因出现肺部转移死亡,余均健在。结论:原发性鼻腔-鼻窦透明细胞癌较罕见,早期症状以鼻出血多见,病理学上需与转移性透明细胞癌及多种含透明细胞的涎腺肿瘤鉴别。治疗以手术切除联合放化疗为主,短期内预后较好。早期局限于鼻腔和鼻窦的有基底的肿瘤可考虑鼻内镜手术,术后建议每半年复查一次。
Objective: To investigate the clinical manifestations and pathological features of primary clear cell carcinoma of the nasal cavity and to summarize its diagnosis and treatment. Methods: To analyze the clinical data of one case of primary clear cell carcinoma of the nasal cavity and review 11 cases of related literature since 1992, and make a summary report. Results: Eight cases (66.7%) of primary nasal-sinus clear cell carcinoma showed mainly epistaxis and four cases (33.3%) had bone destruction. CT showed similar soft tissue density in nasal cavity and paranasal sinus Three cases (25.0%) were treated by simple surgical resection. Seven cases (58.3%) were treated by radiotherapy and chemotherapy combined with chemoradiotherapy (2 cases, 16.7%). All patients were followed up for 6 months to 10 years. Only 1 patient died of lung metastasis. Conclusions: Primary nasal-sinus clear cell carcinoma is rare. Early symptoms are common in nasal hemorrhage. Pathologically, it is necessary to differentiate it from metastatic clear cell carcinoma and many kinds of salivary gland tumors with clear cell. The treatment of combined chemoradiation with surgical resection, the prognosis is good in the short term. Early confined to the nasal and sinus basal tumors may consider endoscopic sinus surgery, postoperative recommendations once every six months review.