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目的观察卡维地洛对应用血管紧张素转换酶抑制剂(ACEI)等基础治疗的充血性心力衰竭(CHF)患者心功能的影响。方法将88例充血性心力衰竭患者随机分为两组,治疗组则在常规治疗的基础上给予卡维地洛治疗,对照组行常规治疗使用洋地黄制剂、血管紧张素转换酶抑制剂、利尿剂等。结果用药(卡维地洛)l2个月后治疗组总有效率为93.2%,明显高于对照组的有效率(72.7%),差异有统计学意义(P<0.01)。两组治疗后左室射血分数(LVEF),左室舒张末期内径(LVEDD)、左室收缩末期内径(LEVSD)的变化的差异均有统计学意义(P<0.05)。结论卡维地洛能有效改善心功能,疗效显著,耐受性好,且安全、不良反应少。
Objective To observe the influence of carvedilol on cardiac function in patients with congestive heart failure (CHF), such as angiotensin converting enzyme inhibitor (ACEI). Methods 88 patients with congestive heart failure were randomly divided into two groups. The treatment group received carvedilol on the basis of routine treatment. The control group received routine treatment with digitalis preparations, angiotensin converting enzyme inhibitors, diuresis Etc. Results The total effective rate of the treatment group was 93.2% after 12 months of treatment with carvedilol, which was significantly higher than that of the control group (72.7%), the difference was statistically significant (P <0.01). The differences of LVEF, LVEDD and LEVSD between the two groups after treatment were statistically significant (P <0.05). Conclusion Carvedilol can effectively improve cardiac function, curative effect is obvious, well tolerated, and safe, less adverse reactions.