目的 :研究静脉普罗帕酮转复新发生阵发性心房颤动 (房颤 )。方法 :有症状就诊的经心电图证实为阵发性房颤患者 42例 ,发作时间 <48h ,剔除冠心病急性心肌缺血、心力衰竭、瓣膜性心脏病、病态窦房结综合征、房室传导阻滞及甲亢患者。随机分为静脉普罗帕酮组和静脉毛花甙C组。普罗帕酮组采用 3 5mg ,5min内静脉注射 ,观察 10分钟未发者 ,再加 3 5mg ,最大剂量 14 0mg。毛花甙C组 0 .4mg静脉滴壶入 ,若 4h内不转复再加 0 .2mg。所有患者均在心电监护下观察心电、血压及症状变化。比较两组 4h和 8h的转复率和转复时间。结果 :普罗帕酮组 2 1例 4小时内转复 9例 ,8h内共转复 14例 ,转复率 66.6%;平均复律时间 1.9h。毛花甙C组 8h转复率 3 3 .3 %,平均复律时间 3 .7h。两组均未发生不良反应。结论 :静脉小剂量分次给药 ,普罗帕酮转复阵发性房颤成功率高、安全 ,但需要严格掌握适应证及药物剂量 Objective: To study the effect of intravenous propafenone on paroxysmal atrial fibrillation (AF). Methods: 42 patients with paroxysmal atrial fibrillation who had symptomatic treatment were confirmed to have paroxysmal atrial fibrillation, the onset time was less than 48h, excluding acute myocardial ischemia with coronary heart disease, heart failure, valvular heart disease, sick sinus syndrome, atrioventricular conduction Block and hyperthyroidism patients. Randomly divided into intravenous propafenone group and vein Cetoside C group. Propafenone group with 35mg, 5min intravenous injection, observed 10 minutes without hair, plus 35mg, the maximum dose of 14 0mg. Cysteamine 0.4mg intravenous drip pot C group, if not within 4h plus 0 .2mg. All patients were observed ECG changes in ECG, blood pressure and symptoms. The recovery rate and recovery time of 4h and 8h were compared between the two groups. Results: In propafenone group, 21 cases recovered within 4 hours, 9 cases recovered within 8 hours, 14 cases recovered, the recovery rate was 66.6%, and the average cardioversion time was 1.9 hours. Cysteamine C group 8h recovery rate 33.3%, mean cardioversion time 3. 7h. No adverse reactions occurred in both groups. Conclusion: The low dose intravenous injection, propafenone paroxysmal atrial fibrillation success rate, safe, but need to strictly control indications and drug doses