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大鼠肝细胞癌变过程中,肝细胞核和细胞质的核糖核酸(RNA)的复杂性有改变,这个变化在诱癌的“早期”(2周之内)已出现,并延续在肝细胞癌变的整个过程中。反映了肝细胞基因表达系统的变化。高等生物具有复杂的基因组织,Britten等人应用DNA复性动力学的方法,按其复性速度的快慢,将真核生物的DNA分为单一顺序、中度重复顺序和高度重复顺序三类不同的基因组织,对基因组织的研究深入了一步。
Changes in hepatocellular and cytoplasmic RNA (RNA) complexity during rat hepatocellular carcinogenesis have occurred, and this change has occurred in the “early” (within 2 weeks) of induction of cancer and continues throughout the hepatocellular carcinogenesis Process. It reflects the change of hepatocyte gene expression system. Higher organisms with complex genetic organization, Britten and others using the method of DNA refolding kinetics, according to the speed of its refolding, the eukaryotic DNA is divided into single sequence, moderately repeated sequences and highly repetitive sequences of three different Of the genetic organization, a step into the study of the genomic organization.