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目的观察凋亡抑制蛋白Survivin在肝癌组织中的表达,探讨其表达与Ki-67增殖指数、肝癌切除术后复发、预后的相关性及其临床意义。方法应用免疫组织化学方法检测55例肝癌组织中Survivin、Ki-67的表达。结果Survivin在肝癌组织中的表达率为52．7%,有门脉癌栓或卫星结节的肝癌Survivin表达率明显高于无门脉癌栓或卫星结节者(P＜0．05),Survivin阳性表达的肝癌切除术后1、3年复发率(55．17%、96．55%)明显高于Survivin阴性表达的1、3年复发率(26．91%、73．08%)(P＜0．05),肝癌切除术后Survivin阳性表达的1、3年生存率(58．62%、10．34%)显著低于Survivin阴性表达的1、3年生存率(76．92%、30．71%,P＜0．05)。此外,Survivin阳性表达的肝癌组织Ki-67增殖指数(33．83±18．90)%明显高于Survivin阴性表达的肝癌组织增殖指数(19．60±19．35)%(P＜0．05)。结论Survivin可能通过促进肝癌细胞增殖参与肝癌的发展,其表达与肝癌切除术后复发风险高和预后不良相关,可作为肝癌的预后指标。
Objective To observe the expression of survivin protein in hepatocellular carcinoma (HCC), and to explore its correlation with Ki-67 proliferation index, recurrence and prognosis after hepatectomy and its clinical significance. Methods Immunohistochemistry was used to detect the expression of Survivin and Ki-67 in 55 cases of HCC. Results The positive rate of Survivin expression in HCC tissues was 52.7%. The positive rate of Survivin in portal vein tumor thrombus or satellite nodules was significantly higher than that in portal vein tumor thrombus or satellite nodules (P <0.05) The recurrence rates at 1 and 3 years after Survivin positive hepatocellular carcinoma resection (55.17%, 96.55%) were significantly higher than those at Survivin negative one and 3 years (26.91%, 73.08%) ( Year survival rate (58.62%, 10.34%) of Survivin positive expression after hepatectomy was significantly lower than that of Survivin negative expression of 1,3-year survival rate (76.92% , 30.71%, P <0.05). In addition, the Ki-67 proliferation index (33.83 ± 18.90)% in Survivin-positive hepatocellular carcinoma was significantly higher than that in Survivin-negative hepatocellular carcinoma (19.60 ± 19.35)% ). Conclusion Survivin may be involved in the development of hepatocellular carcinoma by promoting the proliferation of hepatocellular carcinoma cells. The expression of Survivin may be related to the high risk of recurrence after hepatocellular carcinoma resection and the poor prognosis.