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东德药典第7版记载,以121～124°的加压蒸汽经120分钟的加热可以破坏热原。由于尿素输液的不耐热性,故东德药典第7版规定用滤过除菌法制备。文献报导,对于尿素输液的热稳定性曾有过种种说法,有人认为本品受酸、碱的催化而分解,有人将其加热至100°,认为在pH6.2时分解最少,故建议加入缓冲剂。作者以121～124°之温,对尿素输液作不同时间的加热(溶液中含尿素30%)。发现时间越长、分解越多:加热20分钟的,分解标示量为2.5%,60分钟——8.0%,120分钟——16%,180分钟——25%,240分钟——30%。将溶液中尿素的剩余浓度在半对
East German Pharmacopoeia 7th Edition records, to 121 ~ 124 ° pressurized steam heated by 120 minutes can destroy the pyrogen. Due to the heat-insensitivity of urea infusion, the 7th edition of the East German Pharmacopoeia is prepared by filtration sterilization. Reported in the literature, for the thermal stability of urea infusion have been said that some people think that this product by the acid and alkali catalyzed decomposition, it was heated to 100 °, that the decomposition of the least at pH6.2, it is proposed to add a buffer Agent. The author of 121 ~ 124 ° temperature, urea infusion for different time heating (solution containing urea 30%). Found that the longer the decomposition more: 20 minutes of heating, the decomposition of the labeled amount of 2.5%, 60 minutes - 8.0%, 120 minutes - 16%, 180 minutes - 25%, 240 minutes - 30%. The remaining concentration of urea in the solution is half-paired