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目的:分析多囊卵巢综合征(Polycystic ovary syndrome,PCOS)患者的临床特点、内分泌改变和超声特征,并探讨相应指标的诊断意义。方法:研究组收集符合鹿特丹(2006)诊断标准的PCOS患者50例,检测其女性激素包括E2、FSH、LH、PRL、T,此外尚检测其抗苗勒氏管激素(AMH)水平,并使用B超检查测定其卵泡数量。同期选取正常女性23例,作为对照组,亦对上述指标进行测定。比较两组间临床特点、内分泌水平及B超检查等的状况,同时分析AMH的诊断价值。结果:PCOS患者女性激素指标中的LH、LH/FSH和T均高于对照组(P<0.05),而FSH低于对照组(P<0.05),此外,AMH与卵泡数目高于对照组,差异均有统计学意义(P<0.05)。AMH、B超指征与T水平三者联合诊断PCOS特异性最高。结论:测定AMH水平在临床工作中可以协助PCOS的诊疗。
OBJECTIVE: To analyze the clinical features, endocrine changes and ultrasonographic features of patients with Polycystic ovary syndrome (PCOS) and to explore the diagnostic significance of the corresponding indicators. METHODS: The study group collected 50 PCOS patients who met the diagnostic criteria of Rotterdam (2006) and tested for female hormones including E2, FSH, LH, PRL and T, and tested for anti-Mullerian hormone (AMH) B ultrasound examination to determine the number of follicles. In the same period, 23 normal women were selected as the control group, and the above indexes were also measured. The clinical features, endocrine levels and B-ultrasound were compared between the two groups, and the diagnostic value of AMH was analyzed. Results: The levels of LH, LH / FSH and T in female patients with PCOS were significantly higher than those in control group (P <0.05), while those in FSH group were lower than those in control group (P <0.05) The differences were statistically significant (P <0.05). AMH, B-indications and T-levels combined diagnosis of PCOS highest specificity. Conclusion: The determination of AMH levels in clinical work can assist the diagnosis and treatment of PCOS.