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目的:介绍中国前瞻性城乡流行病学(PURE-China)研究的设计与方案,并对研究的合理性进行说明。方法:本研究来源于国际多中心队列前瞻性城乡流行病学(PURE)研究的中国现场。研究拟纳入40 000名中国社区人群,涉及全国12个省市的100余家社区,分布在我国东部、中部、西部地区的城市和农村。研究将从社区、家庭、个体这三个水平收集研究对象的人口统计学资料、既往疾病史、生活方式(吸烟、饮酒、体力活动及膳食)等信息,同时对研究对象进行基础的体格检查和生化检查,并测量心电图。研究随访将至少持续10年,以观察慢性非传染性疾病及其危险因素随城市化进程发生的变化。结果:PURE-China研究自2005年至2009年间进行受试者招募,共纳入研究对象46 285人,其中城市22 807人(49.3%),农村23 478人(50.7%)。东部地区入选24 807人,其中城市12 232人(49.3%),农村12 575人(50.7%);中部地区入选10 182人,其中城市5 058人(49.7%),农村5 124人(50.3%);西部地区入选11 296人,其中城市5517人(48.8%),农村5 699人(51.2%)。结论:本研究收集了中国城乡人群社会学因素与慢性非传染性疾病的重要信息,设计与方案合理,可以为我国慢病防治政策的制定提供参考依据,以缓和社会发展对健康带来的不利影响。
OBJECTIVE: To introduce the design and program of the PURE-China prospective urban and rural areas in China and to explain the rationality of the study. METHODS: This study was derived from the Chinese site of the prospective urban-rural epidemiology (PURE) study of the international multicenter cohort. The study plans to include 40,000 Chinese community groups, covering more than 100 communities in 12 provinces and cities nationwide, in cities and rural areas in the eastern, central and western regions of China. The study will collect demographic information, past disease history, lifestyle (smoking, drinking, physical activity and diet) from the three levels of community, family and individual, and conduct basic physical examination of the subjects and Biochemical examination, and measurement of electrocardiogram. The follow-up study will last at least 10 years to observe the changes of chronic non-communicable diseases and their risk factors with the process of urbanization. RESULTS: The PURE-China study recruited 46 285 subjects from 2005 to 2009, of which 22,807 were urban residents (49.3%) and 23 478 (50.7%) were rural residents. There were 24,807 persons in the eastern region, of which 12,232 were urban residents (49.3%) and 12,575 were rural residents (50.7%); 10,182 were selected from the central region, including 5,058 (49.7%) urban residents and 5,124 (50.3% ); 11 296 were enrolled in the western region, of which 5517 were urban residents (48.8%) and 5 699 (51.2%) were rural residents. Conclusions: This study collected important information about sociological factors and chronic non-communicable diseases in Chinese urban and rural population. The design and scheme are reasonable and can provide a reference for the formulation of chronic disease prevention and control policies in our country so as to ease the adverse health effects of social development influences.