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目的观察三氧化二砷(As2O3)联合全反式维甲酸(ATRA)治疗急性早幼粒细胞白血病(APL)的疗效及毒副反应。方法患者使用三氧化二砷联合全反式维甲酸双诱导治疗,对高白细胞患者加用单一化疗药物高三尖衫酯碱(H)或柔红霉素(DNR),合并弥漫性血管内凝血(DIC)患者予以输注血浆/纤维蛋白原。结果29例患者中26例完全缓解,完全缓解(CR)率89.66%;3例死于颅内出血。结论三氧化二砷联合全反式维甲酸治疗急性早幼粒细胞白血病的疗效确切,患者耐受性较好。
Objective To observe the curative effect and toxicity of arsenic trioxide (As2O3) combined with all-trans retinoic acid (ATRA) in the treatment of acute promyelocytic leukemia (APL). Methods Arsenic trioxide combined with all-trans retinoic acid double induction therapy was used. Patients with high white blood cell count were treated with single chemotherapy drug Trichotreet (H) or daunorubicin (DNR). Patients with diffuse intravascular coagulation (DIC) Infusion of plasma / fibrinogen. Results Among the 29 patients, 26 patients were completely relieved and the complete remission (CR) rate was 89.66%. Three patients died of intracranial hemorrhage. Conclusion Arsenic trioxide combined with all-trans retinoic acid in the treatment of acute promyelocytic leukemia is effective and the patient is well tolerated.