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目的：：探讨九味镇心颗粒治疗广泛性焦虑障碍的疗效与安全性。方法：112例广泛性焦虑障碍患者随机分为研究组和对照组，每组56例，分别给予九味镇心颗粒和帕罗西汀治疗，疗程6周。采用汉密尔顿焦虑量表( HAMA)观察两组疗效，采用副反应量表(TESS)观察两组药品不良反应。结果：两组治疗后2周HAMA评分均较前明显下降(P0.05)。两组治愈率、有效率比较，差异均无统计学意义(P>0.05)。研究组不良反应发生率为14.8%，低于对照组的22.6%(P0.05)。结论：九味镇心颗粒治疗广泛性焦虑障碍疗效与帕罗西汀相仿，但不良反应较少，安全性好。“,”Objective:To explore the curative effect and security of Jiuwei Zhenxin granules in the treatment of generalized anxiety disorder. Methods:Totally 112 patients with generalized anxiety disorder were randomly divided into the research group and the control group with 56 ones in each. The research group was given Jiuwei Zhenxin granules while the control group was given paroxetine with the treatment course of 6 weeks. The curative effect of the two groups was observed using Hamilton anxiety scale ( HAMA) , and the side effects were observed using treatment energent eymptom scale( TESS) . Results:After the 2-week treatment, HAMA scores were signifi-cantly lower than those before the treatment (P0. 05). The recovery rate and effective rate of the two groups also showed no statistically significant differences (P >0.05). The incidence of adverse drug reactions in the research group was 14. 8%, which was lower than that in the control group (22. 6%, P0. 05). Conclusion:Jiuwei Zhenxin granules show similar effect with paroxetine in the treat-ment of generalized anxiety disorder with lower adverse reaction incidence and promising safety.