论文部分内容阅读
整体脑Ｍ受体代谢动力学实验表明，老年小鼠脑Ｍ受体的生成和降解均慢于青年对照，前者减慢的程度超过后者，导致生成和降解速率的失平衡，从而使受体密度在降低水平上达到新的稳态，知母水提物长期口服同时促进脑Ｍ受体的合成和降解，对合成的加快作用更强，所以知母提高衰老时脑Ｍ受体密度的机制主要在促进受体分子的生成，从而纠正生成和降解的失平衡。离体实验中知母有效成分ＳＡＲ对脑Ｍ受体与３Ｈ－ＱＮＢ的结合无竞争作用，故知母的上述作用并非属于Ｍ受体拮抗剂的性质。
Overall brain M receptor metabolic kinetics experiments showed that the generation and degradation of brain M receptors in aged mice was slower than that of young controls. The former slowed down more than the latter, leading to imbalances in the rate of production and degradation, thus making the receptor The density reaches a new steady state at a reduced level. The long-term oral administration of Rhizoma Anemarrhenae water extract simultaneously promotes the synthesis and degradation of brain M receptors, and has a stronger accelerating effect on the synthesis. Therefore, the mechanism of the Anemarrhenae sinensis increasing brain M receptor density during aging is increased. It mainly promotes the production of receptor molecules, thereby correcting the imbalance between production and degradation. In vitro, the active ingredient SARS of Anemarrhenae has no competition effect on the binding of brain M receptor to 3H-QNB, so the above-mentioned effects of Anemarrhenae Zhimu are not attributed to M receptor antagonists.