论文部分内容阅读
目的观察克拉霉素联合呋喃唑酮治疗老年胃溃疡的效果。方法将老年胃溃疡患者46例按数字表法随机分为观察组和对照组各23例。对照组给予呋喃唑酮治疗;观察组在对照组治疗的基础上给予克拉霉素治疗。比较2组患者的治疗效果。结果观察组总有效率明显高于对照组,复发率明显低于对照组,差异均有统计学意义(P<0.05)。治疗前2组患者胃镜下溃疡直径差异无统计学意义(P>0.05);治疗后2组患者的溃疡直径均小于治疗前,且观察组小于对照组,差异有统计学意义(P<0.05)。观察组幽门螺杆菌转阴率高于对照组,差异有统计学意义(P<0.05)。治疗前2组患者生活质量评分差异无统计学意义(P>0.05);治疗后2组患者的生活质量评分均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。结论克拉霉素联合呋喃唑酮治疗老年胃溃疡效果显著,消除病因,临床症状得到缓解,加快了溃疡愈合,减少老年胃溃疡的复发,提高了患者的生活质量,值得临床推广应用。
Objective To observe the effect of clarithromycin combined with furazolidone in the treatment of senile gastric ulcer. Methods 46 cases of elderly patients with gastric ulcer were randomly divided into observation group and control group according to the digital table method in 23 cases. The control group was treated with furazolidone; the observation group was treated with clarithromycin on the basis of the control group. Compare the treatment effect of 2 groups of patients. Results The total effective rate of the observation group was significantly higher than that of the control group, the recurrence rate was significantly lower than the control group, the difference was statistically significant (P <0.05). There was no significant difference in the diameter of gastric ulcer between the two groups before treatment (P> 0.05). After treatment, the ulcer diameter of the two groups was less than before treatment, and the observation group was smaller than the control group (P <0.05) . The negative rate of Helicobacter pylori in the observation group was higher than that in the control group, with significant difference (P <0.05). There was no significant difference in quality of life between the two groups before treatment (P> 0.05). After treatment, the quality of life scores of the two groups were higher than before treatment, and the observation group was higher than the control group (P < 0.05). Conclusion Clarithromycin combined with furazolidone has significant effect on the treatment of senile gastric ulcer. Eradication of the etiology, alleviation of clinical symptoms, acceleration of ulcer healing, reduction of recurrence of senile gastric ulcer and improvement of patient quality of life are worthy of clinical application.