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1993年1月至1997年12月,我院对收治的肺癌脑转移患者的其中21例进行了以鬼臼甲叉甙(VM-26)为主的化疗配合放疗的综合治疗。其中非小细胞肺癌18例,小细胞肺癌3例,脑转移灶均经CT或MRI证实。男性19例,女性2例,平均年龄55岁。 联合化疗方案:VM-26100mg+0.9％NS250ml静滴,1～3d(或1～5d);顺铂(DDP)20mg+0.9％NS250ml静滴,1～5d,3～4周为1疗程,共计4～6疗程。化疗前给20％甘露醇250～500ml+地塞米松5～10mg静滴使用,降低颅高压同时也有利血脑屏障的开放。1995年以后又对放疗后的化疗再加上长春地辛(VDS)3mg+0.9％NS500ml静滴,1d,8d。放疗:
From January 1993 to December 1997, 21 patients with lung cancer brain metastases admitted to our hospital underwent comprehensive treatment with chemotherapy based on VM-26 and radiotherapy. Including 18 cases of non-small cell lung cancer, 3 cases of small cell lung cancer, brain metastases were confirmed by CT or MRI. There were 19 males and 2 females with an average age of 55 years. Combined chemotherapy: VM-26100mg+0.9% NS250ml intravenous infusion, 1 to 3d (or 1 to 5d); cisplatin (DDP) 20mg+0.9% NS250ml intravenous infusion, 1 to 5d, 3 to 4 weeks as a course of treatment, total 4 to 6 courses of treatment. Before chemotherapy, 20% mannitol 250 ~ 500ml + dexamethasone 5 ~ 10mg intravenous infusion, reducing the intracranial hypertension but also conducive to the opening of the blood-brain barrier. After 1995, chemotherapy plus radiotherapy (VDS) 3mg + 0.9% NS 500ml intravenous infusion, 1d, 8d after radiotherapy. Radiotherapy: