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目的:研究银黄清肺胶囊联合左氧氟沙星治疗下呼吸道肺炎支原体感染的临床效果。方法:选取医院呼吸内科2013年1月—2015年8月收治的96例下呼吸道肺炎支原体感染的患者并将其按数字表法分为对照组和观察组,每组48例患者。对照组患者仅用左氧氟沙星治疗,观察组患者采用银黄清肺胶囊联合左氧氟沙星治疗。对比两组患者治疗效果,体温恢复时间、咽痛消失时间、胸片病灶消失时间、治愈时间,治疗前后外周血白细胞(WBC)与C-反应蛋白(CRP)的变化情况。结果:观察组治疗后的总有效率(93.75%)明显高于对照组的(79.17%),统计学有意义(P<0.05);观察组患者治疗后体温恢复时间(3.25±0.71)d、咽痛消失时间(3.11±0.35)d、胸片病灶消失时间(4.91±0.65)d、治愈时间(5.13±2.41)d明显少于对照组(6.48±0.91)d、(6.15±0.15)d、(13.89±2.74)d、(8.95±6.66)d,具有统计学意义(P<0.05);两组患者治疗后WBC、CRP水平较治疗前均降低,且观察组治疗后WBC(4.01±0.03)×10~9/L、CRP(4.58±0.08)mg/L水平明显低于对照组治疗后WBC(4.31±0.21)×10~9/L、CRP(5.24±2.28)mg/L水平,具有统计学意义(P<0.05)。结论:下呼吸道肺炎支原体感染的患者采用银黄清肺胶囊联合左氧氟沙星治疗的效果显著,可以明显缩短体温恢复时间、咽痛消失时间、胸片病灶消失时间、治愈时间,安全性高,值得在临床上推广。
Objective: To study the clinical effect of Yinhuang Qingfei Capsule combined with levofloxacin in the treatment of Mycoplasma pneumoniae infection of lower respiratory tract. Methods: Ninety-six patients with Mycoplasma pneumoniae infection from January 2013 to August 2015 in our hospital were selected and divided into control group and observation group according to the digital table method, 48 patients in each group. Patients in the control group were treated with levofloxacin only, and patients in the observation group were treated with Yinhuang Qingfei Capsule combined with levofloxacin. The therapeutic effect, body temperature recovery time, disappearance time of sore throat, disappearance time of chest radiograph, cure time, changes of peripheral blood leukocytes (WBC) and C-reactive protein (CRP) before and after treatment were compared between the two groups. Results: The total effective rate (93.75%) in the observation group was significantly higher than that in the control group (79.17%) (P <0.05). The recovery time of body temperature in the observation group was 3.25 ± 0.71 d, The duration of disappearance of sore throat (3.11 ± 0.35) d and the disappearance time of chest lesion (4.91 ± 0.65) d and 5.13 ± 2.41 d were significantly lower than those of control group (6.48 ± 0.91) d and (6.15 ± 0.15) d respectively, (13.89 ± 2.74) d and (8.95 ± 6.66) d, respectively (P <0.05). The WBC and CRP levels in both groups were lower than those before treatment (WBC 4.01 ± 0.03) The level of CRP (4.58 ± 0.08) mg / L was significantly lower than that of WBC (4.31 ± 0.21) × 10-9 / L and CRP (5.24 ± 2.28) mg / L after treatment in the control group Significance (P <0.05). Conclusion: The patients with Mycoplasma pneumoniae infection of lower respiratory tract treated with Yinhuang Qingfei Capsule combined with levofloxacin have significant effect, which can significantly shorten the recovery time of body temperature, the disappearance of sore throat, the disappearance time of chest radiograph, the cure time and high safety. On the promotion.