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目的探讨人乳头状瘤病毒(human papilloma virus,HPV)感染与外阴恶性肿瘤的关系,为外阴恶性肿瘤的防治提供指导。方法本研究选取手术切除治疗并病理确诊的30例外阴恶性肿瘤患者的临床和病理资料,分别用免疫组织化学法(immunohistochemistry,IHC)和原位分子杂交(in situ hybridization,ISH)方法,检测切片中HPV感染情况。结果 30例外阴恶性肿瘤患者中IHC检测HPV表达均为阴性;ISH法检测1例HPV16/18(1/30 3.33%)低度阳性表达,其余均为阴性。结论外阴恶性肿瘤组织中HPV感染率较低,外阴恶性肿瘤发生可能与HPV感染无关。
Objective To investigate the relationship between human papilloma virus (HPV) infection and vulvar malignant tumors and provide guidance for the prevention and treatment of vulvar malignant tumors. Methods The clinical and pathological data of 30 patients with malignant tumors of the vulva treated by surgical resection and pathology were collected. The immunohistochemistry (IHC) and in situ hybridization (ISH) In the case of HPV infection. Results IHC was negative for HPV in 30 cases of vulvar malignant tumor; low positive expression was detected in 1 case of HPV16 / 18 (1/30 3.33%) by ISH method, and the others were all negative. Conclusion The HPV infection rate in vulvar malignant tumors is low, and the occurrence of vulvar malignant tumors may not be related to HPV infection.