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为探讨穿心莲抗动脉粥样硬化的可能机制，用血小板聚集仪、血栓弹力描记仪和ACL－200型凝血仅分别观察了穿心莲成份API0134对实验性动脉粥样硬化家兔血小板聚集率、血栓弹力图和血液凝固性改变的影响。结果发现，动脉粥样硬化模型家兔的血液呈高凝和低纤溶状态，表现为血小板活化因子诱导的血小板聚集显著增强；血栓弹力图的反应时间和凝固时间显著缩短，血栓最大幅度和血栓弹力度显著增大；部分凝血活酶时间明显缩短，优球蛋白溶解时间显著延长。经API0134治疗3天后，上述异常的血凝和纤溶参数显著改善，基本恢复至正常水平。提示，API0134具有抗血小板聚集、抗血栓形成和促进纤溶活性的作用，这种作用可能是其抗动脉粥样硬化的机理之一。
To investigate the possible mechanism of andrographolide against atherosclerosis, platelet aggregation, thrombelastography and ACL-200 coagulation were used to observe the platelet aggregation rate and thromboelastogram of Andrographis paniculata API0134 in experimental atherosclerosis rabbits respectively. And blood coagulation changes. The results showed that atherosclerotic rabbit blood hypercoagulability and fibrinolytic state showed platelet-activating factor-induced platelet aggregation was significantly enhanced; thrombus elastic diagram of the reaction time and coagulation time was significantly shorter, the maximum thrombus and thrombus Elasticity increased significantly; partial thromboplastin time was significantly shortened, euglobulin lysis time was significantly prolonged. After three days of treatment with API0134, the abnormal coagulation and fibrinolysis parameters were significantly improved and returned to normal levels. It is suggested that API0134 has anti-platelet aggregation, anti-thrombosis and fibrinolytic activity. This effect may be one of the mechanisms of anti-atherosclerosis.