急性肾衰(acuterenalfailure,ARF)是一种具有高死亡率的临床综合征。缺血性ARF患者通常伴有多器官功能衰竭和全身性感染,明显增加患者的死亡率。目前有很多有关缺血性ARF的病理生理研究的报道,本文就有关血管的收缩、内皮的损伤、炎症的作用、上皮细胞的反应及其病生机制、缺血 Acute renal failure (ARF) is a clinical syndrome with high mortality. Patients with ischemic ARF are often associated with multiple organ failure and systemic infections, significantly increasing patient mortality. There are many reports on the pathophysiology of ischemic ARF. In this article, we discuss the effects of vascular contraction, endothelial damage, inflammation, epithelial cell response and pathogenesis, ischemia