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目的:探讨剖胸手术对乙型肝炎表面抗原(HBsAg)阳性食管癌患者肝功能的影响。方法:选择100例食管癌手术患者,其中HBsAg阳性50例(病例组),HBsAg阴性50例(对照组),于手术前后分别测定肝功能指标,进行对比分析;定性检测大、小三阳患者手术前后的HBVDNA。结果:HBsAg阳性患者谷丙转氨酶(ALT)术后高于术前(P<0.05);小三阳(HBsAg、HBeAb、HBcAb阳性)患者HBVDNAPCR检出率术后明显高于术前(P<0.05)。结论:剖胸手术对HBsAg阳性食管癌患者肝功能有不同程度的损害作用;术前常规检测乙肝标志物,重视围手术期护肝治疗十分必要。
Objective: To investigate the effect of thoracotomy on liver function in patients with positive esophageal carcinoma of hepatitis B surface antigen (HBsAg). Methods: 100 patients with esophageal cancer were selected, including 50 cases of HBsAg positive (case group) and 50 cases of negative HBsAg (control group). The liver function indexes were measured before and after operation. Before and after the HBVDNA. Results: The positive rates of HBVDNA PCR in HBsAg positive patients were significantly higher than those before operation (P <0.05), and those in HBsAg positive patients (HBsAg, HBeAb and HBcAb positive) were significantly higher than those before operation (P <0.05) . Conclusion: Thoracotomy has a different degree of damage to liver function in HBsAg-positive esophageal cancer patients. It is necessary to routinely detect hepatitis B markers and emphasize perioperative liver protection.