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本文报告我院1987年6月至1989年7月经组织学证实的60例Ⅲ、Ⅳ鼻咽癌期病人,其中30例使用顺铂(20～40mg/周、静脉给药)同时合并常规放射治疗,另30例行单纯放射作为对照。治疗结束时,顺铂+放射组的原灶消失率为99.3％(29/30),单纯放射组为89.7%(26/30),顺铂+放射组的颈部转移灶完全退缩率为33.3％(10/30),单纯放射组为16.7％(5/30),顺铂+放射组毒性反应以胃肠为主(63％),血液毒性轻微,未发现肾毒性和神经毒性。远期效果有待继续观察。
This article reports 60 cases of patients with stage III and IV nasopharyngeal carcinoma confirmed by histology from June 1987 to July 1989 in our hospital. Among them, 30 cases were treated with cisplatin (20-40 mg/week, intravenously) and concurrently with conventional radiation therapy. The other 30 patients received simple radiation as a control. At the end of treatment, the disappearance rate of primary tumors in the cisplatin+radiation group was 99.3% (29/30), in the radiotherapy alone group was 89.7% (26/30), and the complete retraction rate of cervical metastases in the cisplatin+radiation group was 33.3. % (10/30), 16.7% (5/30) in the radiotherapy alone group. The cisplatin+radioactive group was mainly gastro-intestinal (63%). Hemotoxicity was slight and no nephrotoxicity or neurotoxicity was found. The long-term effect remains to be observed.