脑血管疾病位居中国病死率之首,我国卒中发病率约为120~180/10万,死亡率约为60~120/10万。约20%的脑卒中归因于心房颤动(atrial fibrillation,AF)。AF是临床最常见的心律失常~([1]),AF所致脑卒中具有高致残率、高病死率及高复发率等特点,第一年病死率高达50%,第一年累计复发率高达6.9%。其中,非瓣膜性心房颤动(NVAF)患者缺血性脑卒中发生率比正常窦性心律者升 Cerebrovascular disease ranks first in China, the incidence of stroke in China is about 120 to 180 / 100,000, the mortality rate is about 60 to 120 / 100,000. About 20% of stroke is due to atrial fibrillation (AF). AF is the most common clinical arrhythmia ~ ([1]), AF with stroke due to high morbidity, high mortality and high recurrence rate and other characteristics of the first year mortality rate as high as 50%, the first year of cumulative recurrence Up to 6.9%. Among them, non-valvular atrial fibrillation (NVAF) patients with ischemic stroke incidence than normal sinus rhythm