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观察川芎嗪对白三烯C_4、D_4、组织胺、前列腺素F_(2a)、乙酰胆碱等所致豚鼠离体气管条收缩作用的影响,发现除乙酰胆碱外,川芎嗪对其他几种致喘介质均有一定抑制作用,为非竞争性拮抗剂。本实验似可为川芎嗪的平喘作用提供了一定的理论基础。
To observe the effect of Ligustrazine on contractile activity of isolated tracheal strips of guinea pigs induced by leukotrienes C_4, D_4, histamine, prostaglandin F_ (2a), acetylcholine and so on. It was found that ligustrazine, A certain inhibition, non-competitive antagonists. This experiment may provide a theoretical basis for the antiasthmatic effect of ligustrazine.