解整合素 金属蛋白酶 (ADAM)是一新近发现的细胞膜结合糖蛋白家族。ADAM1 2又称融合素 α(meltrin α)。融合素 α参与肌母细胞融合和肌管形成。骨母细胞在分化过程中也表达融合素 α ,表明融合素 α参与骨的形成。培养的人RD横纹肌肉瘤和HU 1肺腺癌细胞株表达融合素 α ,但表达水平较胎盘低。融合素 α的基因和蛋白质结构从N 末端到C 末端依次为前结构域、金属蛋白酶结构域、解整合素样结构域、富半胱氨酸结构域、跨膜结构域、胞浆结构域。 Soluble integrin metalloproteinases (ADAMs) are a newly discovered family of membrane-bound glycoproteins. ADAM1 2, also known as meltrin α. Fusion factor alpha is involved in myoblast fusion and myotube formation. The osteoblasts also express fusinα during differentiation, indicating that fusulin α is involved in the formation of bone. The cultured human RD rhabdomyosarcoma and HU1 lung adenocarcinoma cell lines express fusin [alpha], but at a lower level than the placenta. The gene and protein structure of fusulin alpha is, in order from the N-terminus to the C-terminus, a pre-domain, a metalloprotease domain, a deintegrin-like domain, a cysteine-rich domain, a transmembrane domain, and a cytoplasmic domain.