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目的:观察泮托拉唑与托烷司琼+地塞米松联用治疗肿瘤化疗所致消化道反应的疗效。方法:将96例化疗所致难治性呕吐的患者随机分为2组,在下一周期化疗中泮托拉唑组给予泮托拉唑+托烷司琼+地塞米松,对照组给予托烷司琼+地塞米松。结果:泮托拉唑组在预防食欲不振,抑制恶心、呕吐等方面明显优于对照组(P均<0.05)。结论:泮托拉唑联合托烷司琼防治化疗药物所致消化道反应疗效较好,值得临床推广应用。
Objective: To observe the curative effect of the combination of pantoprazole and tropisetron plus dexamethasone in the treatment of gastrointestinal cancer caused by chemotherapy. Methods: Ninety-six patients with refractory emesis caused by chemotherapy were randomly divided into two groups. In the next cycle of chemotherapy, the pantoprazole group was given pantoprazole + tropisetron + dexamethasone, while the control group was given tropane Secretary Joan + dexamethasone. Results: The pantoprazole group was significantly better than the control group in preventing loss of appetite, nausea and vomiting (all P <0.05). Conclusion: The effect of pantoprazole and tropisetron in preventing and treating digestive tract diseases caused by chemotherapy drugs is good, which is worthy of clinical application.