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神经损伤后轴突是否能有效再生取决于神经元及其微环境对再生的调控.我们曾报道夹伤大鼠坐骨神经后1d,在夹伤部位的神经内膜中出现充斥微管的再生芽;脊髓运动神经元中管蛋白和肌动蛋白基因表达上调,夹伤后5～10d,它们在再生轴突中的转运速度增加.这些都是神经元胞体对轴突再生调控的表现.微环境中的多种神经因子对不同神经元的再生则各有其显著的作用.睫状神经营养因子(CNTF)是近年发现的与神经营养素家族完全没有
Whether the axons can regenerate effectively after nerve injury depends on the regulation of neurons and their microenvironment on the regeneration.We have reported that the regenerative buds with microtubules were found in the neuro-endothelium of the injured area 1 day after wounding the sciatic nerve in rats, The expression of tubular protein and actin gene in spinal motoneurons was up-regulated, and their transport speed in regenerating axons increased from 5 to 10 days after injury.5 These are all manifestations of regulation of axon regeneration by neuronal somatic cells. Of various nerve factors have different effects on the regeneration of different neurons.Ciliary neurotrophic factor (CNTF) is found in recent years and the family of neurotrophins completely no