The presented analog front end(AFE) used to process human bio-signals consists of chopping instrument amplifier(IA),chopping spikes filter and programmable gain and bandwidth amplifier.The capacitorcoupling input of AFE can reject the DC electrode offset.The power consumption of current-feedback based IA is reduced by adopting capacitor divider in the input and feedback network.Besides,IA’s input thermal noise is decreased by utilizing complementary CMOS input pairs which can offer higher transconductance.Fabricated in Global Foundry 0.35 m CMOS technology,the chip consumes 3.96 A from 3.3 V supply.The measured input noise is 0.85 Vrms(0.5–100 Hz) and the achieved noise efficient factor is 6.48. The presented analog front end (AFE) used to process human bio-signals consists of chopping instrument amplifier (IA), chopping spikes filter and programmable gain and bandwidth amplifier. The capacitor coupling input of AFE can reject the DC electrode offset. The power consumption of current-feedback based IA is reduced by adoption capacitor divider in the input and feedback network.Besides, IA’s input thermal noise is decreased by utilizing complementary CMOS input pairs which can offer higher transconductance. Fabrication in Global Foundry 0.35 m CMOS technology, the chip consumes 3.96 A from 3.3 V supply. The measured input noise is 0.85 Vrms (0.5-100 Hz) and the achieved noise efficient factor is 6.48.