降钙素基因相关肽(calcitonin gene-related peptide,CGRP)是迄今发现的最强的舒血管物质,具有多种重要的生物学作用。作为感觉神经主要递质,CGRP主要由背根神经节合成,某些非神经细胞(如淋巴细胞和内皮细胞)也有表达。CGRP的合成与释放受多种因素调节,除辣椒素受体外,肾上腺素受体、血管紧张素受体、神经生长因子受体和一氧化氮等也参与了CGRP合成与释放的调节。 Calcitonin gene-related peptide (calcitonin gene-related peptide, CGRP) is by far the strongest vasodilator found, has a variety of important biological effects. As the main neurotransmitter of sensory nerve, CGRP is mainly synthesized by dorsal root ganglion, and some non-nerve cells (such as lymphocytes and endothelial cells) are also expressed. The synthesis and release of CGRP are regulated by many factors. In addition to capsaicin receptor, adrenergic receptor, angiotensin receptor, nerve growth factor receptor and nitric oxide are also involved in the regulation of CGRP synthesis and release.