目的:总结23例跨前中颅底肿瘤经眶颧额颞下联合入路显微手术的治疗经验。方法:骑跨前中颅底肿瘤23例,均采用经眶颧额颞下联合入路显微切除。分析本组肿瘤的临床、影像学特征、手术方法、手术结果及手术并发症等。结果:全部肿瘤全切除21例,次切除2例,无手术死亡;术后1例对侧视力恶化,2例颞肌肿胀,2例颞肌萎缩。随访6～46个月,无肿瘤复发。结论:眶颧额颞下联合入路是切除跨前中颅底肿瘤的理想入路之一,该入路术中显露范围广,基本勿需脑牵拉,便于行肿瘤全切除及降低术后并发症。 OBJECTIVE: To summarize the experience of 23 cases of anterior and middle skull base tumors treated by orbital zygomatic frontotemporal approach microsurgery. Methods: Twenty-three anterior midline skull tumors were straddled, and were all underwent microsurgical resection of the frontotemporal frontal foramina. Analysis of the clinical tumor, imaging features, surgical methods, surgical results and surgical complications. Results: All tumors were resected in 21 cases and subtotally removed in 2 cases. There was no surgical death. One case had contralateral visual acuity deterioration, 2 cases of temporal muscle swelling and 2 cases of temporal muscle atrophy. Follow-up 6 to 46 months, no tumor recurrence. Conclusions: Frontal orbital zygomatic infratemporal approach is one of the ideal approaches for resection of anterior and middle skull base tumors. This approach has a wide range of operation and minimal need for brain stretch, which facilitates the complete resection of tumor and reduction of postoperative complication.