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目的:检测冠心病(CHD)患者血清超敏C-反应蛋白(hs-CRP)、纤维蛋白原(FIB)和D-二聚体(DD)水平,探讨其在CHD中的临床应用价值。方法:选择CHD患者86例,采用免疫比浊法定量测定hs-CRP和DD,凝血酶凝固时间法(Clauss法)定量测定FIB,并以30例健康对照进行比较。结果:①急性心肌梗死(AMI)组、不稳定型心绞痛组血清hs-CRP、FIB、DD水平均明显高于稳定型心绞痛(SA)组和对照组,差异有统计学意义(P<0.01);②SA组血清hs-CRP水平明显高于对照组,差异有统计学意义(P<0.01);③SA组FIB、DD水平与对照组相比差异无统计学意义(P>0.05)。结论:CHD患者血清hs-CRP、FIB和DD的检测能较好地反映CHD患者的病情程度,有重要的临床应用价值。
Objective: To investigate the serum levels of hs-CRP, fibrinogen (FIB) and D-dimer (DD) in patients with coronary heart disease (CHD) and explore its clinical value in CHD. Methods: Eighty-six CHD patients were selected. The hs-CRP and DD were measured by immunoturbidimetry and FIB by Clauss method. Thirty healthy controls were used to compare the results. Results: ① The levels of serum hs-CRP, FIB and DD in patients with acute myocardial infarction (AMI) and unstable angina pectoris were significantly higher than those in patients with stable angina pectoris (SA) and control groups (P <0.01) ; ② The level of serum hs-CRP in SA group was significantly higher than that in control group (P <0.01); ③ The levels of FIB and DD in SA group were not significantly different from those in control group (P> 0.05). Conclusion: The detection of serum hs-CRP, FIB and DD in patients with CHD can better reflect the severity of CHD patients and has important clinical value.