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目的:探讨无精子症患者遗传学因素与性激素变化的关系。方法:采用回顾性方法对630例无精子症患者进行染色体核型分析,并采用化学发光法测定各组血清中卵泡刺激素(FSH)、黄体生成素(LH)、睾酮(T)和催乳素(PRL)水平。结果:630例无精子症患者中共检出染色体畸变110例,占17.46%,其中性染色体94例,占异常总数的85.45%,常染色体异常16例,占异常总数的14.55%,性染色体数目异常中Klinefelter综合征76例,占异常总数的69.09%;性激素检测中,无论核型正常与否,FSH、LH显著升高,T值降低,其差异有统计学意义(P<0.01),核型异常组FSH、LH升高更为明显。结论:无精子症与遗传因素及性激素改变密切相关,对无精子症患者进行遗传学检查、性激素检查是十分必要的。
Objective: To investigate the relationship between genetics and sex hormones in patients with azoospermia. Methods: A retrospective analysis of 630 cases of azoospermia in patients with karyotype analysis, and the use of chemiluminescence method to determine the serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone (T) and prolactin (PRL) level. Results: Of the 630 azoospermia patients, 110 cases were detected chromosomal aberrations, accounting for 17.46%. There were 94 cases of chromosomal aberrations, accounting for 85.45% of the total number of abnormalities, 16 cases of autosomal abnormalities, accounting for 14.55% of the total number of abnormalities. The number of sex chromosome abnormalities There were 76 cases of Klinefelter syndrome, accounting for 69.09% of the total number of abnormalities. In normal sex hormone test, the levels of FSH and LH were significantly increased and the T value was decreased, the difference was statistically significant (P <0.01) Abnormal group FSH, LH increased more significantly. Conclusion: Azoospermia and genetic factors and sex hormone changes are closely related to azoospermia in patients with genetic testing, sex hormone tests are very necessary.