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作者报告了14例恶性黑色素瘤病人,25个病灶的放射治疗。通常采用_(60)钴或其它常用射线治疗,每日二次,每次1.5Gy。治疗完成后4～8周,11个病灶肿瘤完全消退,1个病灶肿瘤部分消退。25个病灶中只有3个在照射野内局部复发。恶性黑色素瘤放疗疗效不满意的原因主要有①对放疗亚致死性损伤有很强的修复能力;②对潜在致死性损伤有修复能力;③在放疗疗程中可迅速再增殖。另外还有肿瘤细胞乏氧和不进入细胞增殖周期,故限制了放射治疗的作用。针对第一个原因,可采用更高的每次照射剂量或采用高LET射线照射。Overgaar报告35个病灶采用每次高剂量和中子放射,69%完全消退,97%有缩小。针对第二个原因,可采用超分割照射方法,或也可采用高LFT射线照射。针
The authors reported radiotherapy for 14 patients with malignant melanoma and 25 lesions. It is usually treated with _(60) cobalt or other commonly used radiation, twice daily, 1.5 Gy each time. Four to eight weeks after the completion of treatment, tumors in 11 lesions completely subsided, and one lesion partially subsided. Only 3 of the 25 lesions locally recurred in the field. The main reasons for the unsatisfactory effect of malignant melanoma radiotherapy are: 1) strong repair ability for sublethal injury in radiotherapy; 2) repair ability for potentially fatal injury; 3) rapid repopulation during radiotherapy. In addition, tumor cells are hypoxic and do not enter the cell proliferation cycle, which limits the role of radiation therapy. For the first reason, a higher dose per irradiation or high LET radiation can be used. Overgaar reported 35 lesions each using high-dose and neutron radiation, 69% completely resolved, and 97% had reduced. For the second reason, hyperfractionation irradiation can be used, or high LFT radiation can also be used. needle