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目的探讨窒息时新生儿血清总胆汁酸(TBA)、前白蛋白(PAB)变化及其临床意义。方法检测各30例轻度、重度窒息新生儿及20例缺氧缺血性脑病(HIE)新生儿的(TBA)、(PAB)、丙氨酸转氨酶(ALT)、白蛋白(ALB)水平,并设30例正常新生儿为对照。结果轻度、重度窒息儿和HIE新生儿血清TBA、PAB水平与正常儿比较差异均有非常显著性(P<0.001)窒息时血清TBA、PAB水平与Apgar评分均呈线性相关(r=0.571,-0.689,P<0.001),随病情好转血清TBA和PAB水平逐渐恢复正常。结论血清TBA和PAB是反映窒息儿肝功能损害灵敏的生化指标,动态测定血清TBA和PAB水平变化能很好地、灵敏地反映窒息儿肝脏损害情况及病情转归。
Objective To investigate the changes of serum total bile acid (TBA) and prealbumin (PAB) in neonates with asphyxia and their clinical significance. Methods TBA, PAB, ALT and ALB in 30 mild and severe asphyxia neonates and 20 neonates with hypoxic-ischemic encephalopathy (HIE) And 30 cases of normal newborn as a control. Results Serum levels of TBA and PAB in mild and severe asphyxia children and neonates with HIE were significantly lower than those in normal children (P <0.001). Serum levels of TBA and PAB had a linear correlation with Apgar scores at asphyxia (r = 0.571, -0.689, P <0.001), with the improvement of serum TBA and PAB levels gradually returned to normal. Conclusions Serum TBA and PAB are sensitive indicators of liver function impairment in children with asphyxia, and the dynamic changes of serum TBA and PAB levels can reflect the liver damage and prognosis of asphyxiated children well and sensitively.