Livin是细胞凋亡抑制蛋白家族的新成员,与肿瘤的发生相关。它在某些恶性肿瘤中特异性高表达,而在大多数正常成人组织低表达或不表达(除胎盘),故可作为分子标志物而成为肿瘤诱导凋亡治疗的新靶点。在肺癌中它的表达较高并且与放化疗的耐药有关,已有研究表明,它有可能成为免疫治疗或基因治疗的靶点。 Livin is a new member of the apoptosis-inhibitory protein family, which is related to tumorigenesis. It is highly expressed in some malignant tumors and lowly expressed or not expressed in most normal adult tissues (except the placenta), so it can be used as a molecular marker to become a new target of tumor-induced apoptosis. It is highly expressed in lung cancer and is associated with resistance to chemoradiotherapy. Studies have shown that it may become a target of immunotherapy or gene therapy.