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目的 :了解甲状腺机能亢进时胰岛素样生长因子Ⅱ (IGF -Ⅱ )及血清降钙素(CT)含量的变化 ;方法 :采用放射免疫法测定了 1 7例甲亢患者血清IGF -Ⅱ和CT的含量与正常对照组进行比较 ;结果 :1 7例甲亢患者中仅有 2例IGF -Ⅱ和CT较高 ,其它均低于正常对照组 ,P <0 .0 0 1 ,差异显著 ;结论 :甲状腺机能亢进能引起患者骨代谢的异常 ,导致骨质疏松症的发生是CT含量的变化引起的高转换性骨质疏松和IGF -Ⅱ在骨储存库中浓度的下降为主要的因素之一
Objective: To investigate the changes of insulin-like growth factor Ⅱ (IGF-Ⅱ) and serum calcitonin (CT) in patients with hyperthyroidism.Methods: Serum IGF-Ⅱ and CT levels were measured in 17 hyperthyroid patients by radioimmunoassay Compared with the normal control group. Results: Only 2 of 17 hyperthyroid patients had higher IGF-Ⅱ and CT, the others were lower than the normal control group, P <0.01. The difference was significant. CONCLUSION: The thyroid function Hypertension can cause abnormalities in patients with bone metabolism, resulting in the occurrence of osteoporosis is the CT content changes caused by high-conversion osteoporosis and IGF-Ⅱ in the bone bank decline in concentration as one of the main factors